沒有結構的蛋白質如何凝集？陽明生化所改寫「半乳糖凝集素」認知 скачать в хорошем качестве

沒有結構的蛋白質如何凝集？陽明生化所改寫「半乳糖凝集素」認知

凝集素是動物與人體內常見的醣結合蛋白，許多生命現象都經細胞的醣分子和凝集素的結合而產生，影響免疫調控與癌症轉移，也讓科學家可針對這類蛋白結構來設計藥物。然而陽明大學研究「半乳糖凝集素-3」(galectin-3)發現，除了有結構的部分外，沒有結構的區段可以進行「液─液相分離」(liquid-liquid phase separation)，是這個蛋白凝集的關鍵，重新改寫科學界對「半乳糖凝集素-3」的認知，也提供未來設計藥物的全新方向。 #半乳糖凝集素3 #液液相分離 #無序蛋白 Video: 祕書室 Agglutinations are kind of carbohydrate-binding proteins in human and animal body, many cell functions need agglutinations work properly in molecule level such as functions of immune system and processes of carcinoma metastasis. Galectin-3, which is one of agglutinations and also a member of the galectin family, is not like other proteins that are sequential and structural, instead, Galectin-3 has disordered part and its mechanism is largely unknow. Dr. Jie-rong Huang who is an associate professor in Institute of Biochemistry and Molecular Biology of NYMU and his colleagues found “liquid-liquid phase separation” and extracelluar multivalent interactions of galectin-3. This finding revises scientists’ understanding about Galectin-3 and disordered protein and may provide new target for pharmaceutical industries to design new drugs. Galectin3 LiquidLliquidPhaseSeparation #disorderedprotein Video: Secretariat Office