Loop Diuretics | Mechanism of Action, Indications, Adverse Reactions, Contraindications скачать в хорошем качестве

Loop Diuretics | Mechanism of Action, Indications, Adverse Reactions, Contraindications

Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this pharmacology lecture, Professor Zach Murphy breaks down the mechanism, clinical use, and side effect profile of the powerful Loop Diuretics, which are essential medications in the management of fluid overload and volume-dependent hypertension. We begin by exploring how loop diuretics—such as furosemide, bumetanide, torsemide, and ethacrynic acid—inhibit the Na⁺/K⁺/2Cl⁻ cotransporter in the thick ascending limb of the loop of Henle. This results in profound sodium, chloride, potassium, and water excretion, along with calcium and magnesium loss, making them the most potent class of diuretics. The lecture reviews key indications, including acute pulmonary edema, congestive heart failure, cirrhosis with ascites, nephrotic syndrome, chronic kidney disease, and hypercalcemia. You’ll also learn when loop diuretics are preferred over thiazides—especially in cases of reduced renal function. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media   / ninjanerdlectures     / ninjanerdlectures     / ninjanerdlectures   https://x.com/ninjanerdsci/   / ninja-nerd   💬 Join Our Community Discord:   / discord   #ninjanerd #LoopDiuretics #Diuretics