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#biologyfsc #chapter21 #cellcycle #2ndyear Apoptosis. Definition. Internal programmed of events and sequence of morphological changes by which cell commits suicide is collectively called as apoptosis (Greek word that means dropping off or falling off). Causes. Cell death in multicellular organisms is controlled by two fundamentally different ways, i.e., either the cell commits suicide in the absence of survival signals (trophic factors) cells are murdered by killing signals from other cells Effects. Programmed cell death helps in proper control of multicellular development, which may lead to deletion of entire structure (e.g., the tail of developing human embryos) part of structure (e.g., tissue between developing digits). Cell death even controls the number of neurons, because most of the neurons in the human body die during development. Necrosis The cell death due to tissue damage is called necrosis, during which typical cell swells and bursts, releasing the intracellular contents, which can damage neighboring cells and cause inflammation.