Antiplatelet Agents for Secondary Stroke Prevention - Can We Be More Precise? скачать в хорошем качестве

Antiplatelet Agents for Secondary Stroke Prevention - Can We Be More Precise?

Presented At: LabRoots - Precision Medicine Virtual Event 2019 Presented By: Karen Albright, DO, PhD, MPH - Associate Professor of Neurology, SUNY Upstate Medical University Speaker Biography: No Abstract Webinar: Antiplatelet Agents for Secondary Stroke Prevention - Can We Be More Precise? Webinar Abstract: Clopidogrel, an antiplatelet agent frequently used for secondary stroke prevention, is a prodrug that requires both sufficient intestinal absorption and hepatic modification to produce its active metabolite. An individual's ABCB1 alleles affect clopidogrel absorption, while one's CYP2C19 alleles affect activation of this prodrug. Herein, we explore the role of platelet function assays and genotyping of CYP2C19 and ABCB1 in terms of clopidogrel absorption and activation, and its efficacy in platelet inhibition through three patients who experienced recurrent ischemic stroke despite adherence to clopidogrel. Learning Objectives: 1. Describe the role that platelet function phenotype may play in secondary stroke prevention antiplatelet selection in the future. 2. Describe the role that CYP2C19 and/or ABCB1 genotypes may play in secondary stroke prevention antiplatelet selection in the future. Earn PACE Credits: 1. Make sure you’re a registered member of LabRoots (https://www.labroots.com/virtual-even...) 2. Watch the webinar on YouTube or on the LabRoots Website (https://www.labroots.com/virtual-even...) 3. Click Here to get your PACE credits (Expiration date – June 20, 2021 09:00 AM): https://www.labroots.com/credit/pace-... LabRoots on Social: Facebook:   / labrootsinc   Twitter:   / labroots   LinkedIn:   / labroots   Instagram:   / labrootsinc   Pinterest:   / labroots   SnapChat: labroots_inc