Vagus Nerve Modeling with Sim4Life скачать в хорошем качестве

Vagus Nerve Modeling with Sim4Life

The video shows how IT’IS Virtual Population (ViP) anatomical models are applied within the Sim4Life simulation platform (ZMT Zurich MedTech AG, Switzerland) to design, optimize, and evaluate neuromodulation electrodes for stimulating the vagus nerve. First, it is illustrated how a refined functionalized model of the vagus nerve is created. This is done by isolating the segmented 3D structure of the nerve, and adding its internal structure by segmentation and extrusion of a simplified cross section image. Axonal trajectories may be added in arbitrary fascicles using the Sim4Life graphical user interface or via Python scripting, providing a full flexibility and automatization. As a next step, the parameterized electrophysiological models (templates) of the myelinated axons of different calibre (e.g., SENN, Sweeney, McIntyre) are assigned to axon trajectories. Custom electrophysiological axonal models (such as of unmyelinated C fibers or 3D complex neuronal models) can also be imported from model databases to create customized nerve models with arbitrary axonal populations (type of fiber, axonal diameter, statistical distribution, etc.) All variables in the model are available for post-process analysis for customized investigations. Evaluations are simple due to automized titration procedures.