What is MDMA or Ecstasy? What does it do and how is it metabolised? скачать в хорошем качестве

What is MDMA or Ecstasy? What does it do and how is it metabolised?

MDMA, Ecstasy, Molly, Mandy, XTC. What does it do? What happens when people roll, drop and rave? And how does the body deal with MDMA after it is absorbed? This is the first video in a series about recreational drug use. This video is about MDMA, its history, effects, and metabolism. The next video will be about MDMA toxicity and how to manage it. MDMA was synthesised by Merck in 1912 but wasn't used on humans until the 1970s when psychotherapists started experimenting by using it to aid therapy. Shortly after this MDMA started appearing as a street drug and has been a favourite of ravers ever since then. The effects can be divided into three categories: Psychostimulant Autonomic Cardiovascular Metabolism is non-linear because of a process called Mechanism Based Inhibition, whereby the metabolites of MDMA inhibit its own breakdown. This is why a second dose can be much more effective and longer lasting than the first. If you enjoyed the video, please like and subscribe as it helps the YouTube algorithm tell me what worked well. Leave suggestions for video ideas in the comments! Please note, this video is not medical advice References: de la Torre, Rafael*†; Farré, Magí*‡; Roset, Pere N.*‡; Pizarro, Neus*; Abanades, Sergio*‡; Segura, Mireia*†; Segura, Jordi*†; Camí, Jordi*† Human Pharmacology of MDMA: Pharmacokinetics, Metabolism, and Disposition, Therapeutic Drug Monitoring: April 2004 - Volume 26 - Issue 2 - p 137-144 MDMA, methamphetamine, and CYP2D6 pharmacogenetics: what is clinically relevant?https://www.frontiersin.org/article/1... Rodgers JT, Davydova NY, Paragas EM, Jones JP, Davydov DR. Kinetic mechanism of time-dependent inhibition of CYP2D6 by 3,4-methylenedioxymethamphetamine (MDMA): Functional heterogeneity of the enzyme and the reversibility of its inactivation. Biochem Pharmacol. 2018 Oct;156:86-98. doi: 10.1016/j.bcp.2018.08.010. Epub 2018 Aug 13. PMID: 30114388; PMCID: PMC6512342. Bernschneider-Reif S, Oxler F, Freudenmann RW. The origin of MDMA ("ecstasy")--separating the facts from the myth. Pharmazie. 2006 Nov;61(11):966-72. PMID: 17152992.