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Lucinda Bateman, MD, delivered a presentation to the ME/CFS International Conference 2021: RID - Research Innovation and Discovery. Orthostatic intolerance (OI) is the development of symptoms in an upright posture that is relieved or partially relieved by reclining. In this presentation, Dr. Bateman reviews OI: symptoms assessment research data hours of upright activity (HUA) as a measure of function triggers interventions (pharmacological and non-pharmacological) "Treatment can improve symptoms and function and may lead to insight about the underlying disease process." We advise viewers to carefully review and understand the ideas presented and seek the advice of medical providers with any questions you may have as it relates to your patient-specific situation. *************** Funding for BHC educational programming (which includes provider development & presentation time) is provided in part by R. Harold Burton Foundation and the Joseph & Kathleen Sorenson Legacy Foundation.