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Organic electrochemical transistors (OECTs) make effective use of ion injection from an electrolyte to modulate the bulk conductivity of an organic semiconductor channel. The coupling between ionic and electronic charges within the entire volume of the channel endows OECTs with high transconductance compared with that of other transistor technologies. The synthetic tunability, facile integration with flexible substrates and biocompatibility of organic materials make OECTs particularly suitable for applications in biological interfacing. This talk will focus on OECTs embedded on ultrathin organic films and designed to record electrophysiological signals. These devices, tested on cutaneous (electroencephalography, electrocardiography, electromyography) as well as implantable configurations (animal models, clinic) display superior signal-to-noise ratio compared to electrodes due to local signal amplification. The talk will end with a critical look at the future of OECT research and development. Chris Proctor is a Research Associate at the University of Cambridge. This talk was presented at the Arm Research Summit, 17-19 September 2018. Summit 2019 will be taking place in Austin, TX. Visit arm.com/summit for more details!