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Percutaneous Pleural Biopsy for Pleural Effusion is a minimally invasive diagnostic procedure used when the cause of a pleural effusion remains unclear after initial tests like thoracentesis. It’s especially useful for detecting malignancy or tuberculosis. 🛠️ Procedure Overview Technique: Similar to thoracentesis, performed at the bedside using a specialized needle (e.g., Abrams, Cope, or Tru-cut). Steps: Local anesthesia is administered. A biopsy needle is inserted through the chest wall into the pleural space. Tissue samples are taken from the parietal pleura, often at multiple angles (3, 6, and 9 o’clock) to improve diagnostic yield. A chest X-ray is done afterward to check for complications like pneumothorax. 🔍 Indications Undiagnosed exudative pleural effusion Suspected tuberculosis or malignancy Pleural thickening, nodularity, or masses on imaging Cytologically negative pleural fluid ⚠️ Contraindications & Risks Coagulopathy or bleeding disorders Local infection at biopsy site Pneumothorax (8–18% risk) Hemothorax, pain, or infection3 📈 Diagnostic Yield Tuberculosis: Up to 80% sensitivity when granulomas are present Malignancy: Variable, often lower than thoracoscopic biopsy Combined with pleural fluid cytology: Improves accuracy 🧠 Alternatives Image-guided biopsy (ultrasound or CT): Higher yield and safety Thoracoscopic biopsy: Gold standard, especially for mesothelioma or diffuse pleural disease #Pleural