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#161

In this “Ask Me Anything” (AMA) episode, Peter and Bob dive deep into nicotine, a complicated and interesting molecule that has effects on both the brain and the body. They analyze the results of the studies that describe nicotine’s cognitive benefits and potential for inducing weight loss. They talk about a smoking cessation technique called nicotine replacement therapy and give a full breakdown of the various routes of administration, dosing, and safety. Finally, they explore the fascinating and counterintuitive observation that cigarette smokers are less likely to get a severe case of COVID-19. In this sneak peek, we discuss: 00:00:00 - Intro 00:00:10 - How Peter first became interested in the potential benefits of nicotine 00:06:00 - Untangling nicotine from tobacco 00:09:50 - Nicotine replacement therapy (NRT) for quitting smoking: products, protocols, and a review of the literature 00:16:40 - The cognitive benefits of nicotine: Overview of the literature This is a special sneak peek of AMA #23. To view the full video, you'll want to become a podcast subscriber. You can subscribe to the podcast and learn more about all the subscriber benefits: https://peterattiamd.com/subscribe. In the full episode, we also discuss: -Where nicotine has the most positive impact on cognition -Possible mechanisms conferring the benefits of nicotine -How modafinil and other nootropics compare to nicotine -How nicotine may induce weight loss -Relationship between smoking and COVID-19: Analyzing the observation that smoking appears protective against COVID-19 -Breakdown of the various nicotine replacement therapies: route of administration, dosing, and safety -Concluding thoughts on nicotine: use cases, addictive properties, and more Show notes page: https://peterattiamd.com/ama23 -------- About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 30 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://peterattiamd.com Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle