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In this video, renowned experts Dr. Michael Rinaldi and Dr. Vinod Thourani delve into the practical applications of the SENTINEL™ Cerebral Protection System (CPS), highlighting insights from the PROTECTED TAVR study, the largest randomized TAVR trial involving 3,000 patients at over 50 global sites. SENTINEL CPS demonstrated a 60% relative risk reduction in disabling stroke through a secondary analysis, despite no significant overall stroke reduction within 72 hours. Learn from real-world cases, expert insights, and cutting-edge advancements in embolic protection during TAVR procedures. Join and learn more about improving patient outcomes in TAVR. Safety info: https://bit.ly/3lCB31t ©2025 Boston Scientific Corporation or its affiliates. All rights reserved. All trademarks are the property of their respective owners. Prior to use, please see the complete “Directions for Use” for more information on Indications, Contraindications, Warnings, Precautions, Adverse Events, and Operator’s Instructions at www.IFU-BSCI.com. Rx only. SH-1473902-AA | CRM-2110407-AA Chapters: 0:00 - Introduction to the PROTECTED TAVR Study and SENTINEL CPS 0:44 - Stroke in TAVR Overview 5:04 - Opportunities to Prevent Procedural Strokes 6:45 - Insights from TAVR Registries on Stroke Risks 8:18 - Role of Cerebral Embolic Protection in TAVR 8:44 - Overview of SENTINEL CPS 10:49 - SENTINEL IDE Trial Results 13:10 - Registry Data and Observations on Stroke Reduction 16:10 - PROTECTED TAVR Trial: Overview and Objectives 16:49 - PROTECTED TAVR Trial: Results 17:54 - Safety Profile and Subgroup Analyses 19:05 - UK PROTECTED TAVR Trial and Future Data 22:06 - Long-Term Costs and Impact of TAVR-Related Strokes 27:00 - Case Example Introduction 28:18 - Case Example 1: Major Stroke and SENTINEL Adoption 33:28 - Case Example 2: Bicuspid Valve with Severe Calcification 36:45 - Captured Debris and Clinical Outcomes 42:04 - Final Thoughts: Stroke Prevention and SENTINEL's Efficacy