Tumor Metabolism: Connecting Diet to Cellular Metabolism скачать в хорошем качестве

Tumor Metabolism: Connecting Diet to Cellular Metabolism

Tumor cells exhibit metabolic alterations that support their increased proliferation, and can they often acquire nutrients from the extracellular environment to support their cellular metabolism. In this Cell Press Virtual Panel, our panel discusses the links between diet, extracellular nutrient availability, and cellular tumor metabolism. This panel brings together experts in the field of tumor metabolism: Jason Locasale from Duke University, Katy Wellen from the University of Pennsylvania, and Thales Papagiannakopoulos from New York University. Moderated by Molecular Cell editor Krista Bledsoe. For more virtual panels and to explore the breadth of Cell Press cancer research, join us in celebrating Cancer Research week https://www.cell.com/cancer-research-... Click the time stamp to jump to the most relevant question and discussion. 01:13 How do tumor cells sense and take up nutrients from the microenvironment? What is the contribution of extracellular uptake compared with de novo synthesis? 10:47 How does diet affect the availability of nutrients in the tumor microenvironment and alter tumor cell metabolism at the molecular level? 21:20 How might changes in nutrient availability or fuel choice create therapeutic vulnerabilities in tumor cells? 32:40 Can you talk about the models used to study the effects of diet, nutrient availability, or fuel choice on cellular tumor metabolism? What are the challenges of these studies and translating the findings to patients with cancer? 43:09 What do you think are the most exciting areas of investigation or recent discoveries in this area of tumor metabolism? For a full transcript of this panel, visit http://crosstalk.cell.com/blog/tumor-...