Nutritional Determinants of Health... (5) - Mathilde Touvier (2022-2023) скачать в хорошем качестве

Nutritional Determinants of Health... (5) - Mathilde Touvier (2022-2023)

Colloque 2022-2023 : Nutritional Determinants of Health: Recent Research Discoveries and Translation into Public Health Action Conférence du 28 juin 2023 : Host Microbiome Interaction in Health and Disease Intervenant : Pr Eran Elinav, M.D., Ph.D. | Head, Systems Immunology Department, Weizmann Institute of Science | Director, Microbiome & Cancer Division, DKFZ, Heidelberg, Germany The mammalian intestine contains trillions of microbes, a community that is dominated by members of the domain Bacteria but also includes members of Archaea, Eukarya, and viruses. The vast repertoire of this microbiome functions in ways that benefit the host. The mucosal immune system co-evolves with the microbiota beginning at birth, acquiring the capacity to tolerate components of the community while maintaining the capacity to respond to invading pathogens. The gut microbiota is shaped and regulated by multiple factors including our genomic composition, the local intestinal niche, and multiple environmental factors including our nutritional repertoire and bio-geographical location. Moreover, it has been recently highlighted that dysregulation of these genetic or environmental factors leads to aberrant host-microbiome interactions, ultimately predisposing to pathologies ranging from chronic inflammation, obesity, metabolic syndrome, and even cancer. We have identified various possible mechanisms participating in the reciprocal regulation between the host and the intestinal microbial ecosystem, and demonstrate that disruption of these factors, in mice and humans, leads to dysbiosis and susceptibility to common multi-factorial disease. Understanding the molecular basis of host-microbiome interactions may lead to the development of new microbiome-targeting treatments. Retrouvez les enregistrements audios et vidéos du cycle : https://www.college-de-france.fr/fr/a... Chaire Santé publique Professeure : Mathilde Touvier Retrouvez ses enseignements : https://www.college-de-france.fr/fr/c... Le Collège de France est une institution de recherche fondamentale dans tous les domaines de la connaissance et un lieu de diffusion du « savoir en train de se faire » ouvert à tous. Les cours, séminaires, colloques sont enregistrés puis mis à disposition du public sur le site internet du Collège de France. Découvrez toutes les ressources du Collège de France : https://www.college-de-france.fr Suivez-nous sur : Facebook :   / college.de.france   Instagram :   / collegedefrance   LinkedIn :   / collègedefrance   Threads : https://www.threads.net/@collegedefrance Bluesky : https://bsky.app/profile/college-de-f... Facebook :   / college.de.france   Instagram :   / collegedefrance   LinkedIn :   / coll%c3%a8gedefrance