IgG4-RD and Treatment | IgG4ward! Fireside Chat скачать в хорошем качестве

IgG4-RD and Treatment | IgG4ward! Fireside Chat

What are the best treatment options for IgG4-related disease (IgG4-RD)? In this IgG4ward! Fireside Chat, Dr. John Stone is joined by Dr. Arezou Khosroshahi and Dr. Guy Katz to break down the latest approaches to treating IgG4-RD—starting from steroids and moving toward long-term options like B-cell depletion therapy. Topics covered in this conversation: When to start treatment for IgG4-RD How steroids (like prednisone) are used—and why we aim to reduce them B-cell depletion explained: rituximab vs. inebilizumab Side effects, monitoring, and vaccine timing New therapies in development, including oral and cell-based options Patient and caregiver questions—answered live by our experts Use the chapter guide below to jump to the topics that matter most to you. Helpful Links & Resources: 👉 Explore our website: https://igg4ward.org 👉 Mental Health Resource Hub: https://igg4ward.org/mental-health/ 👉 IgG4 Me App (Launching soon!) 👉 Learn More about the PeachJAM – Our Atlanta Patient Event: https://bit.ly/igg4wardpeachjam 👉 Subscribe to our channel for future Fireside Chats and educational content Featuring: Dr. John Stone | Executive Chair, IgG4ward! Foundation Dr. Arezou Khosroshahi | Emory University Dr. Guy Katz | Massachusetts General Hospital 💬 Have a question or idea for a future Fireside Chat? Let us know in the comments. 00:00 - Welcome & What’s New at IgG4ward! 04:00 - Introducing Today’s Fireside Chat on Treatment 06:50 - IgG4ward! Updates: PeachJAM, Mental Health Hub, IgG4 Me App 11:10 - Segment 1: When Should IgG4-RD Be Treated? 20:00 - CT Scans, IgG4 Levels & Individualized Decisions 24:30 - Q&A: Treat or Wait? What If My IgG4 Is Mildly Elevated? 25:50 - Segment 2: Understanding Steroids in IgG4-RD 31:30 - When to Start Steroids—and When to Stop 34:00 - Why B-Cell Depletion May Be a Better Long-Term Option 40:00 - Segment 3: What Is B-Cell Depletion? 43:00 - Rituximab vs. Inebilizumab: Key Differences 46:10 - Benefits of B-Cell Depletion (Flare Reduction, Less Steroids) 49:20 - Risks: Infections, Vaccination Timing, Hypogammaglobulinemia 52:00 - Q&A: How Do You Time Vaccines with Treatment? 55:00 - Segment 4: New Treatments on the Horizon 58:00 - Obexelimab – A B-Cell Down-Regulator 01:00:00 - BTK Inhibitors & Oral Options in Development 01:01:45 - CAR-T & ACE-1831: Cell-Based Therapies in the Future 01:04:05 - Segment 5: Live Q&A from the Community 01:05:00 - Jaw Pain, Submandibular Gland, and TMJ—How to Tell the Difference 01:08:00 - Can We Monitor B Cells in the Body? 01:10:00 - How Do You Know if Treatment Is Working? 01:14:00 - Should I Combine Rituximab with MMF? 01:15:40 - What If I Decline Before My Next Infusion? 01:20:00 - Eosinophilic Angiocentric Fibrosis—A Subtype of IgG4-RD? 01:22:00 - Markers Doctors Use to Assess Treatment Response 01:24:00 - How Long Will I Need B-Cell Therapy? What If I’m in Remission? 01:28:00 - Will B-Cell Depletion Help Rheumatoid Arthritis Too? 01:29:00 - Are Pancreas or Islet Cell Transplants Ever Used? 01:30:00 - What Is Hypogammaglobulinemia and How Is It Managed? 01:31:50 - Thank You & What’s Next: Retroperitoneal Fibrosis and More #IgG4RD #IgG4RelatedDisease #AutoimmuneDisease #RareDisease #Rituximab #Inebilizumab #Steroids #BCellDepletion #DrJohnStone #PatientEducation #PeachJAM #IgG4ward