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00:00 - what is Desvenlafaxine Khedezla - Pristiq / Desvenlafaxine Khedezla - Pristiq pharmacological category 00:05 - what is the USFDA approved indication for Desvenlafaxine Khedezla - Pristiq / labeled indication for Desvenlafaxine Khedezla - Pristiq 00:10 - what are off label uses of Desvenlafaxine Khedezla - Pristiq / off label uses of Desvenlafaxine Khedezla - Pristiq / can Desvenlafaxine Khedezla - Pristiq treat hot flashes 00:19 - what is US BOXED warning for Desvenlafaxine Khedezla - Pristiq / can Desvenlafaxine Khedezla - Pristiq cause suicidal deaths Major depressive disorder Vasomotor symptoms associated with menopause Desvenlafaxine Khedezla - Pristiq Brand Names: Canada AG-Desvenlafaxine; APO-Desvenlafaxine; APO-Desvenlafaxine ER; JAMP-Desvenlafaxine; Pristiq; PRO-Desvenlafaxine; TEVA-Desvenlafaxine Antidepressant, Serotonin/Norepinephrine Reuptake Inhibitor US Boxed Warning Suicidal thoughts and behavior: Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. These studies did not show an increase in the risk of suicidal thoughts and behaviors with antidepressant use in adults older than 24 years; there was a reduction in risk with antidepressant use in adults 65 years and older. In patients of all ages who are started on antidepressant therapy, monitor closely for worsening and for emergence of suicidal thoughts and behaviors. Advise families and caregivers of the need for close observation and communication with the prescriber. Desvenlafaxine is not approved for use in pediatric patients.