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Endoscopic ultrasound (EUS), or echo-endoscopy, is a minimally invasive procedure that helps to diagnose diseases of the gastrointestinal tract. It is a low-risk diagnostic procedure that combines both endoscopy and ultrasound to create detailed images of the digestive tract. A fine-needle aspiration may also be performed during EUS for the extraction of tissue samples to perform a biopsy that aids in the detection of a malignancy. Direct endoscopic necrosectomy (DEN) is a minimally invasive procedure for the treatment of walled-off pancreatic necrosis (WOPN). WOPN, formerly known as pancreatic abscess, is the enclosed collections of pancreatic or peripancreatic necrosis. It is a late complication of acute pancreatitis, which is the swelling of the pancreatic tissue. Direct endoscopic necrosectomy had a higher rate of successful resolution than standard endoscopic drainage (88% vs. 45%), with complications being limited to mild periprocedural bleeding, which was at an equivalent rate between the two groups (32% vs. 20%). It is a minimally invasive technique that can be safely performed on patients who are severely ill. Delayed intervention usually leads to improved outcomes and is currently preferred to early intervention. Because maturation of the necrotic tissue (WOPN) facilitates the procedure of necrosectomy, it is recommended that interventions be performed at least four to six weeks after the onset of acute pancreatitis. It also helps to reduce the risk of complications such as bleeding and perforation.