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Reference: https://www.videogie.org/article/S246... The utilization of knife-assisted techniques for the excision of flat dysplastic lesions associated with colitis represents a significant advancement in therapeutic approaches. This method allows for precise removal of abnormal tissue while minimizing damage to surrounding healthy structures. By employing specialized instruments, clinicians can effectively target dysplastic areas, thereby enhancing the likelihood of successful outcomes and reducing the risk of recurrence. In the context of colitis, where the presence of dysplastic lesions can complicate the disease course, knife-assisted resection offers a strategic solution. The procedure not only addresses the immediate concern of dysplasia but also contributes to the overall management of colitis by potentially preventing the progression to colorectal cancer. The careful application of this technique requires a thorough understanding of the underlying pathology and the anatomical considerations unique to each patient. Furthermore, the implementation of knife-assisted resection necessitates a multidisciplinary approach, involving gastroenterologists, surgeons, and pathologists to ensure comprehensive care. Post-operative monitoring and follow-up are crucial to assess the effectiveness of the intervention and to detect any signs of recurrence early. As research continues to evolve in this area, the refinement of knife-assisted techniques may lead to improved patient outcomes and a better quality of life for those affected by colitis and its associated complications.