Acid Degradable Lipid Nanoparticles Enhance the Delivery of mRNA скачать в хорошем качестве

Acid Degradable Lipid Nanoparticles Enhance the Delivery of mRNA

Presented By: Niren Murthy Speaker Biography: Dr. Niren Murthy is a professor in the Department of Bioengineering at the University of California at Berkeley. Dr. Murthy received his Ph.D. from the University of Washington in Seattle in Bioengineering in 2001, and then did Postdoctoral research at U.C. Berkeley in Chemistry from 2001-2003. He started his academic career at Georgia Tech in 2003 and in 2012 moved back to U.C. Berkeley. Dr. Murthy’s laboratory is an interdisciplinary laboratory that focuses on the development of new materials for drug delivery and molecular imaging. Murthy laboratory has developed several new biomaterials and imaging agents, such as the maltodextrin based imaging agents, which are focused on improving the treatment and diagnosis of infectious diseases. In addition, Murthy laboratory has developed numerous reagents for detecting radical oxidants, such as the hydrocyanines. Webinar: Acid Degradable Lipid Nanoparticles Enhance the Delivery of mRNA Webinar Abstract: The development of acid degradable linkers that rapidly hydrolyze at endosomal pHs is a central problem in the field of drug delivery. Acid degradable linkages are challenging to develop because of their instability. In this report we present a new acid degradable linker based on an azide-acetal, which rapidly hydrolyzes at endosomal pHs but has exceptional stability at pH 7.4. The azide-acetal linkage hydrolyzes via a two-step mechanism that requires reduction and acid hydrolysis and has a unique combination of stability and rapid triggerable hydrolysis. The azide-acetal has a hydrolysis half-life of days at pH 7.4 and can be conveniently synthesized and incorporated into delivery... Earn PACE Credits: 1. Make sure you’re a registered member of Labroots (https://www.labroots.com/) 2. Watch the webinar on YouTube or on the Labroots Website (https://www.labroots.com/ms/webinar/a...) 3. Click Here to get your PACE credits (Expiration date – October 23, 2026): (https://www.labroots.com/credit/pace-... Labroots on Social: Facebook:   / labrootsinc   Twitter:   / labroots   LinkedIn:   / labroots   Instagram:   / labrootsinc   Pinterest:   / labroots   SnapChat: labroots_inc