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In this episode, we discuss common genetic and proteins implicated with Autism. This episode is all about preparing for a future episode about Excitation and Inhibition imbalance- a known phenomena with Autism. I play Tug-of-War with Barbed-Wire and talk about a critical factor of our environment implicating proteins and development- This is huge, and necessary. Genomic Architecture of Autism https://www.cell.com/cell/pdf/S0092-8... PTEN and mTOR https://www.cell.com/cell-reports/ful... 16p11.2, Serotonin, and Possible Social Deficit Rescues https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.nature.com/articles/s4158... https://www.nature.com/articles/s4138... https://www.ncbi.nlm.nih.gov/pmc/arti... Dr. Jack Kruse on Autism https://jackkruse.com/category/autism/ Cullin 3 / Cul3 https://pubmed.ncbi.nlm.nih.gov/31455... SHANK3 https://pubmed.ncbi.nlm.nih.gov/?term... Neurexin and Neuroligin https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.sciencedirect.com/science... (0:00) Introduction; Excitation and Inhibition; (3:15) Phosphate and Tensin- Pten; Synapses, Soma Size, Migration, Cellular Spine Density, Dendritic Overgrowth, Myelination; mTOR (Rapamycin) and hope; Are cells doing what they should? (10:18) 16p11.2; Serotonin; Raphe and Nucleus Accumbens; Possible Therapeutic Help; (13:40) NEED TO KNOW INFORMATION; Tryptophan, Aromatic Amino Acids, UV-B Light and Proteins; Changes in our Light Environment and Implications to our Biology and Modern Health Concerns; Photoreceptors and Brain and Skin Connection- Neuroectoderm; Circadian Mismatch; (19:24) Back to 16p11.2 and Cortical Development; (22:00) Cullin 3 and Cul3 and Implications to Socialness and Sensory-Gating; Causes of Stereotypic Behaviors; Neuronal Excitability; (24:09) SHANK3; Tissues and Brain; Synaptic Implications; more Spine and Dendritic formation; Sensory Processing; Repetitive Behaviors; Anxiety; Social Deficits; Poor Motor Coordination; (25:59) Neurexin and Neuroligin; Synaptic development and action; Myelination; E/I and Spine; CNTNAP2 and mPFC (29:25) Wrap Up and Contact Information email: info.fromthespectrum@gmail.com Chapters: 0:00:00 - Introduction and Excitation and Inhibition 0:03:14 - Chapter 1 0:03:15 - Phosphate and Tensin- Pten 0:10:17 - Chapter 3 0:10:18 - 16p11.2 0:13:39 - Chapter 5 0:13:40 - NEED TO KNOW INFORMATION; HUMAN BIOLOGY and LIGHT 0:19:23 - Chapter 7 0:19:24 - more 16p11.2 0:21:59 - Chapter 9 0:22:00 - Cullin 3 and Cul3 0:24:08 - Chapter 11 0:24:09 - SHANK3 0:25:58 - Chapter 13 0:25:59 - Neurexin and Neuroligin 0:29:24 - Chapter 15 0:29:25 - Wrap Up and Contact Information