常用的化疗药物及剂量有哪些 王霞 山西省肿瘤医院 скачать в хорошем качестве

常用的化疗药物及剂量有哪些 王霞 山西省肿瘤医院

常用的化疗药物及剂量有哪些 王霞 山西省肿瘤医院 膀胱癌分为非肌层侵入性、肌层浸润性和转移性膀胱癌三种类型。非肌层侵入性的标准治疗方法，首选经尿路路膀胱肿瘤切除术，术后根据非肌层侵入性的膀胱尿路上皮癌的复发危险因素决定膀胱内灌注治疗的方案。常用的化疗药物和剂量包括：丝裂霉素20~60毫克、吡柔比星30毫克、表柔比星50~80毫克，第4种是羟基喜树碱40毫克。以上各种药物中最常用的是吡柔比星40毫克溶于生理盐水40~60毫升中进行膀胱灌注，每周一次，共进行4~8次膀胱灌注。随后维持治疗每个月一次，共6~12个月。卡介苗膀胱灌注适用于高危病人，常规剂量是卡介苗120~150毫克。首程于术后两周开始，每周一次，共6周，其主要的副作用是膀胱刺激症。 What are the commonly used chemotherapy drugs and dosage Bladder cancer can be divided into three types: non myoinvasive, myoinvasive and metastatic. Standard treatment for non myometrial invasion, Transurethral resection of bladder tumor is the first choice, According to the recurrence risk factors of non muscle invasive bladder urothelial carcinoma, the plan of intravesical instillation therapy was determined. Commonly used chemotherapy drugs and doses include: mitomycin 20-60 mg, pirarubicin 30 mg, epirubicin 50-80 mg, The fourth is HCPT 40 mg. The most commonly used drug is pirarubicin 40 mg dissolved in normal saline 40-60 ml for bladder perfusion, Once a week, The bladder was perfused 4 to 8 times. And then maintenance therapy once a month, 6-12 months in total. BCG intravesical instillation is suitable for high risk patients, The normal dose is 120-150 mg BCG. The first course began two weeks after operation, Once a week, 6 weeks in total, The main side effect is bladder irritation.