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Early use of double-guidewire technique to facilitate selective bile duct cannulation:the multicenter randomized controlled trial Naoki Sasahira, Hiroshi Kawakami, Hiroyuki Isayama, Rie Uchino, Yousuke Nakai, Yukiko Ito, Saburo Matsubara, Hirotoshi Ishiwatari, Minoru Uebayashi, Hiroshi Yagioka, Osamu Togawa, Nobuo Toda, Naoya Sakamoto, Junji Kato, Kazuhiko Koike It is unclear whether use of the double-guidewire technique facilitates selective bile duct cannulation during endoscopic retrograde cholangiopancreatography (ERCP) and reduces post-ERCP pancreatitis as compared with repeated single-guidewire cannulation. In a large prospective randomized study, Sasahira et al. concluded that the success of selective bile duct cannulation was similar with the two methods (early use of the double-guidewire method 98%, repeated single-guidewire method 97%). The corresponding post-ERCP pancreatitis rates were 20% and 17%; however, the double-guidewire technique was more effective in malignant biliary strictures. Bibliography DOI http://dx.doi.org/ 10.1055/s-0034-1391228 Published online: 15.1.2015 Endoscopy 2015; 47: 421–429 © Georg Thieme Verlag KG Stuttgart · New York ISSN 0013-726X