Mechanism of CELL MEDIATED TOXICITY скачать в хорошем качестве

Mechanism of CELL MEDIATED TOXICITY

Cytotoxic T lymphocytes (CTLs) are generated by immune activation of cytotoxic T cells (Tc cells). They are generally CD8+, which makes them MHC class I restricted. CTLs are able to eliminate most cells in the body since most nucleated cells express class I MHC molecules. In this pathway, a Fas ligand (FasL) on the CTL binds to Fas receptor (FasR) on the target cell. This pathway is independent of granzymes. Instead it involves Interleukin-1β converting enzyme (ICE; also known as Caspase 1) activation, which is similar to granzyme B. This ultimately leads to DNA fragmentation.