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Air date: Wednesday, January 26, 2011, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local Category: Wednesday Afternoon Lectures Description: In this talk, Dr. Harris will discuss the approach she has developed over the last two decades of combining bench work at the University of California, Berkeley, with field work in Nicaragua to investigate the pathogenesis, immunology and epidemiology of dengue and influenza. She will describe the long-term pediatric cohort study ongoing in Managua, Nicaragua, and epidemiological insights that have been derived about dengue and influenza and possibly interactions between the two. She will also discuss her work on a dengue mouse model of antibody-dependent infection and lethal disease that allows mechanistic investigation of the role of natural and therapeutic antibodies in protection and pathogenesis, and how this interfaces with parallel studies of dengue immunology in human populations. Finally, this work underscores the importance of long-term collaborations in global health and partnerships for sustained scientific capacity building in developing countries. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. Author: Eva Harris, Ph.D., Professor of Infectious Diseases and Director of the Center for Global Public Health at the University of California at Berkeley, and President of the Sustainable Sciences Institute Runtime: 01:05:11 Permanent link: http://videocast.nih.gov/launch.asp?1...