Pouchitis (Inflammation of ileal pouch) ; Definition, causes, symptoms, Diagnosis, Treatment скачать в хорошем качестве

Pouchitis (Inflammation of ileal pouch) ; Definition, causes, symptoms, Diagnosis, Treatment

Pouchitis is inflammation of the ileal pouch, which is a complication of restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) surgery. Types: 1. Acute pouchitis 2. Chronic pouchitis 3. Recurrent pouchitis Causes/Risk Factors: 1. Alteration of gut microbiota 2. Ischemia 3. Chronic inflammation 4. Infection (bacterial, viral) 5. Immunogenic predisposition 6. Smoking 7. Non-steroidal anti-inflammatory drugs (NSAIDs) Symptoms: 1. Diarrhea 2. Abdominal pain 3. Rectal bleeding 4. Urgency 5. Tenesmus 6. Fever 7. Weight loss Diagnosis: 1. Pouch endoscopy 2. Biopsy 3. Stool tests (e.g., fecal occult blood) 4. Imaging studies (e.g., MRI, CT scan) 5. Pouchoscopy Treatment: Medications: 1. Antibiotics (e.g., metronidazole, ciprofloxacin) 2. Anti-inflammatory medications (e.g., aminosalicylates) 3. Immunomodulators (e.g., azathioprine) 4. Probiotics Lifestyle Modifications: 1. Dietary changes (e.g., high-fiber diet) 2. Stress management 3. Smoking cessation 4. Regular exercise Complications: 1. Chronic pouchitis 2. Pouch failure 3. Dysplasia 4. Cancer 5. Fistula formation #Pouchitis