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It’s safe to say that we’re all trying to make sense of 2020 — and Self-Evident is aimed at just that. Be sure to check it out! • What It’s Like to Reinvent Yourself (Feat.... How do you stop pepper burn if you can’t drink milk? This week Sam and George suffer for science. #peppers #burn #spicyfood You might also like: How Does Tear Gas Work? • How Does Tear Gas Work? The Chemistry of Sriracha: Hot Sauce Science • The Chemistry of Sriracha: Hot Sauce Science How Does Pepper Spray Work? • How Does Pepper Spray Work? The Chemistry of Pepper: The Spice that Changed the World • The Chemistry of Pepper: The Spice that Ch... Credits: Executive Producers: George Zaidan Hilary Hudson Producers: Andrew Sobey Elaine Seward Writer/Host: Samantha Jones, PhD Scientific consultants: John Hayes, PhD Alissa Nolden, PhD Michelle Boucher, PhD Lelia Duman, PhD Sources: Capsaicin https://www.ncbi.nlm.nih.gov/books/NB... The chemistry of a chili https://www.compoundchem.com/2014/01/... Understand spiciness: mechanism of TRPV1 channel activation by capsaicin https://www.ncbi.nlm.nih.gov/pmc/arti... Capsaicin, Nociception and Pain https://www.ncbi.nlm.nih.gov/pubmed/2... Capsaicin: Risks and Benefits https://www.uspharmacist.com/article/... The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation. https://www.ncbi.nlm.nih.gov/pubmed/1... Integrative Approaches to Pain Management https://www.sciencedirect.com/science... The cool science of hot peppers https://www.sciencenewsforstudents.or... Unraveling the mystery of capsaicin https://www.ncbi.nlm.nih.gov/pmc/arti... Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses https://www.ncbi.nlm.nih.gov/pmc/arti... Capsaicin may have important potential for promoting vascular and metabolic health https://www.ncbi.nlm.nih.gov/pmc/arti... Capsaicin chemical structure https://pubchem.ncbi.nlm.nih.gov/comp... Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases https://www.ncbi.nlm.nih.gov/pmc/arti... Capsaicin: An Uncommon Exposure and Unusual Treatment https://www.ncbi.nlm.nih.gov/pmc/arti... Antimicrobial and Anti-Virulence Activity of Capsaicin Against Erythromycin-Resistant, Cell-Invasive Group A Streptococci https://www.ncbi.nlm.nih.gov/pmc/arti... Perceptual and Affective Responses to Sampled Capsaicin Differ by Reported Intake https://www.ncbi.nlm.nih.gov/pmc/arti... Personality factors predict spicy food liking and intake https://www.ncbi.nlm.nih.gov/pmc/arti... Capsaicin Improves Glucose Tolerance and Insulin Sensitivity Through Modulation of the Gut Microbiota-Bile Acid-FXR Axis in Type 2 Diabetic db/db Mice. https://www.ncbi.nlm.nih.gov/pubmed/3... Learning to Like Spicier Food https://www.theatlantic.com/health/ar... Why some people can tolerate the world’s hottest pepper https://scienceline.org/2016/12/why-s... Advice on building tolerance (from a non-expert) https://www.pepperscale.com/spicy-foo... Are People Born With A Tolerance For Spicy Food? https://www.popsci.com/science/articl... Serious Eats on how to build your spicy foods tolerance https://www.seriouseats.com/2010/08/h... A randomized, double-blind, positive-controlled, 3-way cross-over human experimental pain study of a TRPV1 antagonist (V116517) in healthy volunteers and comparison with preclinical profile. https://www.ncbi.nlm.nih.gov/pubmed/2... Chili peppers for weight loss https://www.tandfonline.com/doi/abs/1... Anti-obesity Effect of Capsaicin in Mice Fed with High-Fat Diet Is Associated with an Increase in Population of the Gut Bacterium Akkermansia muciniphila https://www.frontiersin.org/articles/... Milk for chili peppers (Kool Aid?) https://www.sciencedaily.com/releases... Do Genetics Shape Your Spicy-Food Threshold? https://firstwefeast.com/features/201... Ask the doctor: How does hot pepper cream work to relieve pain? https://www.health.harvard.edu/pain/h... Why do some like it hot? Genetic and environmental contributions to the pleasantness of oral pungency https://www.sciencedirect.com/science... Produced by the American Chemical Society. Join the American Chemical Society! http://bit.ly/Join_acsmembership