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We were delighted to welcome clinicians and basic and clinical researchers from around the world to Rome, Italy, for the triennial International Scientific Symposium: a four-day, state-of-the-art meeting in which new research on clinical advances and the molecular and pathogenic mechanisms underlying EDS and related syndromes were discussed. Due to the pandemic, the International Scientific Symposium had been delayed from 2020, but now that travel restrictions have eased, we were so happy that we could join together in person again. The International Consortium on EDS and HSD brought together leading experts, clinicians, and scientists in the field of EDS and HSD for a high-quality, scientific program with a focus on Translational Medicine in EDS and HSD – from Basic Science to Community. Live simultaneous translations allowed participants to listen to the talks in Italian, French, and Spanish.