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Oral administration of drugs to laboratory rats may be done via drinking water, food or an oropharyngeal gavage. Experts in the field of laboratory animal science (GV-SOLAS; TVT) stress that the most gentle method should be performed. Instead of spending some time to think about a more animal-friendly way, the long-established oropharyngeal gavage is still widely used. The benefits of the gavage are that it is traditional, it allows the application of a very exact amount and once the technique is mastered it can be performed very quickly. However, if the experimenter has not master the gavage perfectly, the well-being of the rat may be impaired by stress. Additionally, a serious risk of injuries in the upper gastro-intestinal tract is given. The refinement method of choice is to teach the rats to cooperate and freely feed on drug- feed mix right out of a pipette. This method is not just cruelty-free but can provide an exciting part in the life of the laboratory rat. It forces the experimenter to create a relationship of trust that will benefit the well-being of the rats throughout the whole experiment. I created the demonstrated protocol for the scientist of our department.