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What is the official and layman's definition of oral lichen planus? What are the different types of oral lichen planus and their characteristics? How common is oral lichen planus and who is most likely to develop it? What are the most common symptoms of oral lichen planus, and how do patients typically describe them? What part of the body is most commonly affected by oral lichen planus? What are the potential causes and underlying pathophysiology of oral lichen planus? How is oral lichen planus diagnosed, and what are the findings in a biopsy? What are the first, second, and third line treatments for oral lichen planus? Who is typically involved in diagnosing and managing oral lichen planus? What does a "band of immune cells (lymphocytes)" in a biopsy report indicate? Important Highlights: Oral lichen planus is a chronic inflammatory condition where the immune system mistakenly attacks the oral mucosa. It presents with various symptoms, the hallmark of which is lacy white patches in the mouth, often accompanied by inflammation and redness. Oral lichen planus affects around 1-2% of the population and is more common in females, over 40, smokers, and diabetics. The pathophysiology of oral lichen planus involves T lymphocytes attacking cells of the oral mucous membrane, triggered potentially by medications, dental materials, or infections. Biopsy is the gold standard for diagnosis, with findings often including a band-like infiltration of lymphocytes at the junction of the epithelium and connective tissue. The first line of treatment typically involves topical corticosteroids, with systemic corticosteroids, immunosuppressant medications or retinoids as second line treatment options. Diagnosis of oral lichen planus often involves a collaborative effort between various healthcare professionals, including dentists, oral surgeons, pathologists, and in complex cases, oral and maxillofacial surgeons or oral pathologists. A "band of immune cells (lymphocytes)" in a biopsy report typically indicates a localized immune response in the affected oral mucosa. By Ian Furst - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index... By James, Candice, Mai - http://bohone09.wikispaces.com/Group+1, CC BY-SA 3.0, https://commons.wikimedia.org/w/index... By Björn S... - Tree Moss - Pseudevernia furfuracea, CC BY-SA 2.0, https://commons.wikimedia.org/w/index... https://dermnetnz.org/topics/oral-lic...