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Hypotension Differential | Classify & Treat All 4 Shock Types | M3 Medical Education A patient rolls in with BP 70/40, confused, tachycardic, and clammy. Do you know exactly what to do? In this video, we build a complete framework for the hypotension differential — from the physiology of MAP = CO × SVR all the way through a stepwise clinical algorithm that classifies all 4 shock types and matches treatment to mechanism. ────────────────────────────────── 📌 TOPICS COVERED ────────────────────────────────── • Physiology of hypotension: MAP = CO × SVR — why this equation IS your differential • Shock definition: hypotension + end-organ hypoperfusion + cellular hypoxia • The 4 shock types and their hemodynamic profiles (CO, SVR, filling pressures) • The board pearl: LOW SVR = DISTRIBUTIVE ONLY (all others = high SVR) • Distributive shock: Sepsis, Anaphylaxis, Neurogenic (bradycardia!), Adrenal Crisis • Cardiogenic shock: AMI, myocarditis, arrhythmia, valvular — high filling pressures • Hypovolemic shock: hemorrhagic vs non-hemorrhagic — low filling pressures • Obstructive shock: Tamponade (Beck's triad), Tension PTX (clinical diagnosis!), Massive PE, Constrictive pericarditis (Kussmaul sign) • Bedside discriminators: warm vs cold skin, JVP assessment, exam findings by shock type • Diagnostic testing: lactate, POCUS RUSH protocol (Pump · Tank · Pipes), targeted labs • 4-step diagnostic algorithm: End-organ dysfunction? → Warm or cold? → Full or empty? → Echo? • Management by mechanism: vasopressors, inotropes, volume resuscitation, obstruction relief • Septic shock vasopressor ladder: NE (1st) → vasopressin (2nd) → epinephrine (3rd) • Anaphylaxis: IM epinephrine FIRST — before antihistamines • Massive transfusion protocol: 1:1:1 blood products • Summary high-yield table: all 4 shock types with can't-miss diagnoses, tests, and treatment ────────────────────────────────── 📚 SOURCES & REFERENCES ────────────────────────────────── Harrison's Principles of Internal Medicine, 22nd Edition: • p.202 — Orthostatic hypotension, autonomic dysfunction • p.850 — Acute blood loss, hypovolemic shock stages • p.2335–2337 — Critical care approach to shock • p.2353–2358 — Approach to the Patient with Shock (Chapter 314) — Table 314-1: Physiologic classification of shock — Table 314-2: Hemodynamic characteristics of shock types — Table 314-4: Initial laboratory evaluation in shock • p.2354 — Epidemiology of shock by setting (ED and ICU data) • p.2356–2357 — POCUS in shock assessment (Chapter 314) • p.2365–2366 — Sepsis and septic shock management (Chapter 315) • p.2367–2369 — Cardiogenic shock, SCAI classification (Chapter 316) • p.2855–2857 — Anaphylaxis (Chapter 365) • p.3110–3113 — Adrenal insufficiency and adrenal crisis (Chapter 398) • p.3956–3957 — Point-of-care ultrasound / RUSH protocol (Chapter 493) Clinical Guidelines: • Evans L, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. Intensive Care Med. 2021;47(11):1181–1247. PMID: 34599691. DOI: 10.1007/s00134-021-06506-y Additional References: • Freeman R, et al. Orthostatic Hypotension: JACC State-of-the-Art Review. J Am Coll Cardiol. 2018;72:1294. (Background reference) • Shen WK, et al. 2017 ACC/AHA/HRS Guideline for Evaluation and Management of Patients with Syncope. Circulation. 2017;136:e60. (Background reference) ────────────────────────────────── 🎯 EXAM RELEVANCE ────────────────────────────────── This video is high-yield for USMLE Step 2 CK, NBME shelf exams (Internal Medicine, Surgery, Emergency Medicine), and clinical clerkships. Tested concepts include: shock classification, hemodynamic profiles, Beck's triad, Kussmaul sign vs pulsus paradoxus, first-line vasopressors in sepsis, anaphylaxis management, tension PTX as a clinical diagnosis, and the RUSH protocol. The 4-step diagnostic algorithm is a frequently tested reasoning framework. ────────────────────────────────── ⚠️ DISCLAIMER ────────────────────────────────── This video is for educational purposes only and does not constitute medical advice. All patients should consult with their healthcare providers about any health concerns. Always refer to current clinical guidelines and institutional protocols when making clinical decisions. ────────────────────────────────── #Hypotension #ShockTypes #USMLE #Step2CK #MedStudy #ClinicalMedicine #InternalMedicine #EmergencyMedicine #SepticShock #CardiogenicShock #MedicalEducation #M3MedEd #DifferentialDiagnosis #ClinicalReasoning #POCUS