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Schwannoma is a type of nerve sheath tumor that arises from Schwann cells, which are responsible for producing the myelin sheath that insulates peripheral nerves. These tumors are typically benign, slow-growing, and can occur anywhere in the body where peripheral nerves are present. 🧠 Key Features of Schwannomas Origin: Schwann cells of the peripheral nervous system Nature: Usually benign; less than 1% become malignant Growth: Slow-growing and often encapsulated Common Sites: Vestibular nerve (inner ear): known as vestibular schwannoma or acoustic neuroma Spinal nerve roots Peripheral nerves in limbs Symptoms: Painless lump Numbness or tingling Hearing loss, tinnitus, or balance issues (if affecting cranial nerves) Muscle weakness (if compressing motor nerves) 🔬 Histology Antoni A areas: Dense cellular regions with spindle-shaped cells arranged in palisades (Verocay bodies) Antoni B areas: Looser, less cellular regions with a myxoid matrix S-100 protein positive: A marker indicating neural crest origin Encapsulation: Typically well-encapsulated, making surgical removal feasible 🩺 Diagnosis & Treatment Imaging: MRI and CT scans help visualize the tumor Biopsy: Confirms diagnosis and rules out malignancy Treatment Options: Observation: For small, asymptomatic tumors Surgery: Preferred for symptomatic or growing tumors Radiation therapy: Occasionally used for vestibular schwannomas #Schwannoma #Tumor