Synthesis of Diuretics | Medicinal chemistry | SNS Institutions скачать в хорошем качестве

Synthesis of Diuretics | Medicinal chemistry | SNS Institutions

Synthesis of Diuretics Diuretics are drugs that increase urine production, used to treat conditions like hypertension, edema, and heart failure. Here are some common classes and their synthesis routes: 1. Thiazide Diuretics (e.g., Hydrochlorothiazide) Synthesis*: Condensation of *2,4-disulfamoyl-5-chloroaniline with formaldehyde and an aldehyde (e.g., formaldehyde) under acidic conditions, followed by cyclization. *Key step*: Formation of the thiazide ring. 2. Loop Diuretics (e.g., Furosemide) Synthesis*: Reaction of *2,4-dichlorobenzoic acid with *furfurylamine*, followed by sulfonamide formation and carboxylation. *Key step*: Introduction of the sulfonamide group. 3. Potassium-Sparing Diuretics (e.g., Spironolactone) *Synthesis*: Derived from steroidal precursors, involving multiple steps including oxidation, hydrolysis, and cyclization. *Key step*: Formation of the lactone ring. 4. Carbonic Anhydrase Inhibitors (e.g., Acetazolamide) Synthesis*: Reaction of *5-amino-1,3,4-thiadiazole-2-sulfonamide with acetyl chloride. *Key step*: Introduction of the acetamido group. These syntheses involve various organic reactions, including condensation, cyclization, and functional group transformations. Let me know if you'd like more details on a specific diuretic or reaction! #snsinstitutions #snsdesignthinkers #designthinking #snscphs