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Global Perspectives in Urothelial Carcinoma (2025) – German Focus Webcast CME Available: https://auau.auanet.org/node/43893 © 2025 by the American Urological Association Education and Research, Inc. After participating in this CME activity, participants will be able to: 1. Identify new and emerging treatment options in the locally advanced (la)/metastatic urothelial carcinoma (mUC) setting, including combination regimens and optimal sequencing. 2. Analyze mechanisms of action of novel agents in the la/mUC setting. 3. Address the roles of the urologist, medical oncologist, radiation oncologist, and other clinicians in delivering holistic, multidisciplinary care to UC patients. 4. Incorporate AUA and relevant local/regional clinical guidelines updates for UC treatments into practice. 5. Properly manage adverse events associated with therapies for la and mUC and discuss ways to improve early identification. 6. Determine appropriate management strategies to reduce the incidence of AEs to minimize morbidity, including identifying methods to leverage multidisciplinary teams and advanced practice providers to achieve these goals. ACKNOWLEDGEMENTS Support provided by an independent educational grant from: Astellas and Pfizer, Inc.