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Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this lecture, Professor Zach Murphy will guide you through the histology of the liver, exploring its microscopic structure and functional organization. We begin by examining the classic liver lobule, focusing on the arrangement of hepatocytes, sinusoids, and the central vein. From there, we discuss the portal triad, which consists of a branch of the hepatic artery, a branch of the portal vein, and a bile duct, and how this arrangement supports the liver’s dual blood supply and bile transport system. We then analyze the direction of blood flow from the portal triad toward the central vein and the opposite flow of bile toward the bile ducts. This leads to an explanation of the liver acinus model, which highlights metabolic zonation and the susceptibility of different zones to toxins, ischemia, or metabolic stress. Special attention is given to Kupffer cells and hepatic stellate cells, outlining their immune, storage, and fibrotic roles. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media / ninjanerdlectures / ninjanerdlectures / ninjanerdlectures https://x.com/ninjanerdsci/ / ninja-nerd 💬 Join Our Community Discord: / discord #ninjanerd #LiverHistology #Gastrointestinal