2. GnRH Agonist & Antagonists, Antiestrogens, Selected toxicities Hormones and Related Agents скачать в хорошем качестве

2. GnRH Agonist & Antagonists, Antiestrogens, Selected toxicities Hormones and Related Agents

𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩‍⚕‍ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊 📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 :   / clinical.learning   2. GnRH Agonist & Antagonists, Antiestrogens, Selected toxicities Hormones and Related Agents -------------------------------------------------------------------------------------------------------------------------- GnRH agonists and antagonists, antiestrogens, and their selected toxicities form an essential subset of hormone-based therapies targeting the hypothalamic-pituitary-gonadal (HPG) axis to treat prostate cancer, breast cancer, and certain reproductive disorders 🏥🧬. GnRH agonists (e.g., leuprolide, goserelin) initially stimulate gonadotropin release, leading to a transient “flare” of LH/FSH before downregulating pituitary receptors and dramatically reducing sex hormone production (estrogen/testosterone) 🌟🔻. Conversely, GnRH antagonists (e.g., degarelix) block receptor binding without the initial flare, providing a more rapid decline in hormone levels, thus limiting tumor growth in prostate cancer 🚫🩸. Antiestrogens like tamoxifen and raloxifene compete with estrogen receptors in breast tissue, inhibiting proliferative signals crucial for ER-positive breast carcinomas, whereas fulvestrant acts by degrading estrogen receptors, achieving a more profound antiestrogenic effect 🎯💊. However, side effects can include hot flashes, mood swings, bone density changes, and in the case of tamoxifen, a risk of endometrial hyperplasia or malignancy ⚠️🔥. GnRH agonists may induce initial flare symptoms (e.g., worsened bone pain in metastatic prostate cancer) and reduced bone mineral density (osteoporosis risk), while GnRH antagonists avoid the flare but share the potential for hot flashes and sexual dysfunction 🏋️💢. Clinically, these agents are often combined with other targeted or cytotoxic therapies, optimizing tumor control in hormone-sensitive malignancies and improving patient outcomes through precise hormonal modulation 💖🌎. gnrh agonist #GnRHAgonists #GnRHAntagonists #Antiestrogens #Tamoxifen #Fulvestrant #ProstateCancer #BreastCancer #HormoneTherapy #Pharmacology #MedicalScience #USMLE #NEETPG #GlobalHealth #SaveLives #RationalDrugUse #Oncology