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Retinopathy of Prematurity: Stopping Childhood Blindness In this expert-led session from APPNA Pediatrics, we conduct a deep dive into Retinopathy of Prematurity (ROP), a critical vasoproliferative disorder affecting premature infants. As neonatal survival rates increase globally, particularly in Low and Middle-Income Countries (LMICs), the incidence of ROP has surged, making standardized screening and timely intervention more vital than ever. This video serves as a comprehensive clinical guide for neonatologists, pediatricians, and NICU nursing staff to understand the pathophysiology, staging, and treatment of this sight-threatening condition. We explore the latest updates from the International Classification of Retinopathy of Prematurity (ICROP3), providing clarity on how to identify Zone I, II, and III involvement and the nuances of "plus disease." A major focus is placed on the "Double-Edged Sword" of Oxygen Management. Understanding the relationship between oxygen saturation targets and the development of abnormal retinal vasculature is key to any Quality Improvement (QI) project in the neonatal unit. We discuss the transition from the initial hyperoxic phase to the subsequent hypoxic phase that triggers vascular endothelial growth factor (VEGF) overproduction. For clinicians preparing for the USMLE Step 1, Step 3, or Pediatric Boards, this overview covers high-yield topics found in Gomella’s Neonatology, including screening criteria based on birth weight (typically 1500g) and gestational age 30 weeks). We also analyze modern treatment modalities, comparing the long-term outcomes of Laser Photocoagulation versus Anti-VEGF intravitreal injections (such as Ranibizumab or Bevacizumab). Beyond the NICU, we address the critical "blind spot" in neonatal care: post-discharge follow-up. Failure to ensure a "warm handoff" to a pediatric ophthalmologist is a leading cause of late-stage retinal detachment. This session aligns with the APPNA Pediatrics mission to provide world-class medical education, linking neonatal respiratory management (including Jet ventilation and HFOV) with long-term neurodevelopmental and sensory outcomes. Whether you are managing a complex case of Pulmonary Hypertension or fine-tuning TPN and Zinc supplementation, understanding the systemic nature of ROP is essential for holistic neonatal care. Timestamped Chapters: 00:00 Introduction to Retinopathy of Prematurity 02:30 The Global Burden: Why ROP Blindness is Rising 05:15 Pathophysiology: The Two Phases of Retinal Injury 08:45 Oxygen Saturation Targets: Finding the "Sweet Spot" 12:20 ICROP3 Classification: Zones, Stages, and Plus Disease 16:40 Screening Criteria: Who and When to Examine 21:10 Treatment Breakthroughs: Laser vs. Anti-VEGF 25:55 The Critical Importance of Post-Discharge Follow-up 29:30 Quality Improvement: Reducing ROP in Your NICU 33:10 Summary and Expert Clinical Pearls Watch other videos from APPNA Pediatrics: 1 • NAVA Explained: Master Neurally Adjusted V... from / @appnapediatrics 2 • Genetic Testing in Pediatrics: The New Fir... from / @appnapediatrics 3 • First Virtual Neonatology Conference 2025 ... from / @appnapediatrics 4 • Neonatal Mechanical Ventilation Basics: Ph... from / @appnapediatrics 5 • Neonatal Neurocritical Care in LMICs: Savi... from / @appnapediatrics