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For more information on PSA testing or prostate cancer or #YaleMedicine, visit: https://www.yalemedicine.org/conditio.... When everything is functioning as it should, you may not spend a lot of time thinking about your prostate, the walnut-sized gland that sits below the bladder and in front of the rectum. Found only in men, it surrounds the urethra—the tube through which both urine and semen pass—and plays an important role in the male reproductive system, producing the fluid that makes up part of semen. But when something goes wrong with the prostate, it can cause worrying symptoms. Men may have a hard time starting the flow of urine, need to urinate more frequently than usual, and have a weak urinary stream. These and other symptoms are often caused by an enlarged prostate gland, but they can also, in rare cases, result from prostate cancer, which, after skin cancer, is the most common form of cancer in men. Prostate cancer is most often silent (without symptoms) and is detected through prostate cancer screening. Prostate cancer most commonly occurs in men over age 65 and is rare in those under 40. The National Cancer Institute estimates that in 2021, nearly 250,000 men will be diagnosed with the disease and around 34,000 men will die from it. Around one out of every eight men will be diagnosed with it during their lifetime. Though prostate cancer is common, the good news is that there are many treatments for it. If caught at an early stage, it has a good prognosis and, in most cases, can be cured. Prostate cancer screening tests are used to detect cancer at an early stage, before symptoms begin. The prostate-specific antigen (PSA) blood test—the main screening test for prostate cancer—measures the level of PSA, a protein produced by the prostate gland, in the blood. PSA levels may be elevated in men who have prostate cancer. Doctors may also perform a digital rectal exam (DRE) to examine the prostate. In this procedure, the doctor inserts a gloved finger into the patient’s rectum and feels the prostate to check for abnormalities. If a PSA blood test or DRE detect an abnormality, the doctor will order additional tests such as a prostate magnetic resonance imaging (MRI) scan and a prostate biopsy to determine if the patient has prostate cancer. Screening may be offered to men starting around age 50 or 55, though those who are at higher risk for prostate cancer may begin screening testing at age 40 or 45. Men should talk to their doctors about the risks and benefits of screening tests. 0:00 - Risk of prostate cancer 0:29 - PSA test 1:11 - Recommendation