MCOS скачать в хорошем качестве

MCOS

Details of the seminar: Date: October 17, 2025 Time: 15:00 CEST, 9:00 EDT Topic: Metabolic connectivity features in Alzheimer’s disease Speaker: Silvia Paola Caminiti Abstract: Emerging evidence highlights that connectivity alterations in Alzheimer’s disease (AD) include not only hypo-connectivity but also hyper-connectivity, particularly in limbic and cerebellar regions during the prodromal and early dementia stages. In our recent longitudinal multimodal study, we demonstrated that hyper-connectivity is detectable with FDG-PET metabolic connectivity and is not merely compensatory: metabolism in hyper-connected regions mediated parieto-temporal hypometabolism and predicted a faster conversion to dementia. These findings converge with other recent reports showing that medial temporal and anterior-temporal hyper-connectivity mediates amyloid-related tau accumulation and accelerates neurodegeneration. Altogether, converging data suggest that hyper-connectivity, far from being a benign or compensatory feature, may actively drive AD progression by increasing metabolic burden and synaptic inefficiency. Understanding this dual landscape of hypo- and hyper-connectivity offers new insights into AD pathophysiology and may open perspectives for network-based biomarkers of disease progression. Biosketch: Dr. Silvia Paola Caminiti is an Assistant Professor at the Department of Brain and Behavioral Sciences at the University of Pavia in Italy. With a background in neuroimaging and neuroscience, Dr. Caminiti is dedicated to advancing our understanding of the intricacies of the brain and its functioning. Dr. Caminiti’s primary research focus revolves around aging and neurodegenerative diseases. The goal of her research program is to examine selective neuronal vulnerability in Alzheimer’s (AD) and Parkinson’s disease (PD) using multimodal neuroimaging including positron emission tomography (PET) and magnetic resonance imaging (MRI).