Cubane Lore (Cubane Tier List) скачать в хорошем качестве

Cubane Lore (Cubane Tier List)

Use code POGCHEMISTAPR50 for 50% off your first box at https://strms.net/ThatChemistFactorAp... #ad Cubanes are a pretty neat class of molecules – in this video, we explore the applications of cubanes, and rank some impressive cubanes such as BUTTERCUBE! Summary In this, the host discusses Cubane, a cube-shaped molecule, and its potential applications in medicinal chemistry. Cubane is considered as a substitute for Benzene rings in new drug candidates. The 3D structure of Cubane allows for distinct interactions with target proteins or receptors. Additionally, Cubane can have different metabolites compared to Benzene. It is also explored in energetic materials. The video presents a tier list of various Cubane derivatives, highlighting their structures and uniqueness. Highlights 💡 Cubane is a cube-shaped molecule that medicinal chemists want to use as a substitute for Benzene rings in new drug candidates. 💡 Substituting a Benzene ring with Cubane in an active pharmaceutical ingredient (API) could potentially improve binding to the target. 💡 Cubane's 3D structure allows for different interactions in space, unlike the flat Benzene ring. 💡 Cubane derivatives can have different metabolites compared to Benzene, which is important for drug elimination from the body. 💡 Cubane is also explored in energetic materials, although its large-scale production poses challenges. 💡 The tier list of Cubane derivatives ranks them based on their impressive structures, with S tier being the most impressive. 💡 The video acknowledges the need for more commercially available and affordable Cubane derivatives to advance research and drug development. Support the Channel on Patreon -   / thatchemist   Join the Community Discord! -   / discord   Team Writer/Producer - That Chemist (Joey) Editor/Lead Animator - ReformLabs 3D Systems Engineer - Robot Chicken Thumbnail Artist - RinFroggy Acknowledgements Thanks to the people on Twitter who helped suggest cubane references! Especially Kitspiroplatin for the reference of the extremely long tetracubane iodide! I also want to acknowledge that Tom will eventually make cubane. References Tom’s Cubane Series    • Cubane Synthesis   Perfluorocubane    • The First Real Life Pictures EVER of ...   Chemiolis Click Chem    • Click Chemistry in Action: The Chemis...   Casual Chemistry Click Chem    • Copper and Click Chemistry for OLEDs ...   Cubane Review Articles: Cubanes in Med Chem http://doi.org/10.1021/acs.jmedchem.8... Cubanes: 50 Years Later http://doi.org/10.1021/cr500523x Bicubyl https://pubs.acs.org/doi/10.1021/ja98... bidentate cubane ligand https://doi.org/10.1055/s-0029-1217083 butter cubane https://doi.org/10.1016/S0040-4039(00... carboxycubane thioxanthylglycine - https://worldwide.espacenet.com/paten... (page 48) cubane carboxylic acid https://doi.org/10.1002/chem.201901086 cubane dicarboxylic acid dimethyl ester https://doi.org/10.1055/s-0040-1705964 cubane https://doi.org/10.1055/s-1995-3961 cubene https://doi.org/10.1021/ja00229a057 cubyl phenyl ketone https://pubs.rsc.org/en/content/artic... cubyl triflate https://pubs.acs.org/doi/abs/10.1021/... cubylmethanol https://doi.org/10.1021/ol501750k dideuterocubane https://pubs.acs.org/doi/10.1021/jp95... diethynyl cubane https://pubs.acs.org/doi/abs/10.1021/... diflucuburon https://doi.org/10.1002/anie.201510675 letepricube https://worldwide.espacenet.com/paten... mercury cubane insanity https://doi.org/10.1021/cr500523x (compound 71) methoxycarbonylcubane carboxylic acid - 10.1002/chem.201901086 octamethylcubane https://doi.org/10.1016/S0040-4039(00... octacyclopropylcubane https://onlinelibrary.wiley.com/doi/a... octanitrocubane https://doi.org/10.1002/(SICI)1521-37... (this DOI sucks) octaphenylcubane https://pubs.acs.org/doi/abs/10.1021/... perfluorocubane https://doi.org/10.1126/science.abq0516 perfluorooctamethylcubane https://pubs.acs.org/doi/abs/10.1021/... tetracarbomethoxycubane https://link.springer.com/article/10.... tetrabromotetranitrocubane https://pubs.acs.org/doi/10.1021/jo97... pedestal - https://doi.org/10.1002/anie.199214211 Molecules in this Tierlist Bicubyl, bidentate cubane ligand, butter cubane, carboxycubane thioxanthylglycine, cubane carboxylic acid, cubane dicarboxylic acid dimethyl ester, cubane, cubene, cubyl phenyl ketone, cubyl triflate, cubylmethanol, dideuterocubane, diethynyl cubane, diflucuburon, letepricube, mercury cubane insanity, methoxycarbonylcubane carboxylic acid, octamethylcubane, octacyclopropylcubane, octanitrocubane, octaphenylcubane, perfluorocubane, perfluorooctamethylcubane, tetrabromotetranitrocubane, tetracarbomethoxycubane, tin cubane insanity, extremely long cubane, lead cubane insanity