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KEYWORDS: atrophic acne scars, cystic acne, intradermal cellular Adipofilling, Adipopimer, fat storage The treatment of facial acne scars is carried out by means of several techniques. Today, a new, regenerative biological technique is available: Adipofilling. This technique has been made possible by the invention of an economical, disposable, patented device: the Adipopimer. Adipopimer creates a suspension of single, living adipose and stromal cells, which, when injected into the dermis, regenerate the atrophic cutaneous scar tissue. The result starts to become visible within a few weeks. Once the result has become stable, after 3 or 6 months, a further session of intradermal cellular Adipofilling is carried out; this second session uses the 1 mL Luer lock syringes left over from the previous session, which have been conserved at -32°C. The suspensions created by the Adipopimer acquire the property of not freezing, and can be conserved in a normal laboratory freezer. This means that several Adipofilling sessions can be carried out after only one session of liposuction and one session of processing the lipoaspirate with the Adipopimer. In conclusion, treating acne scars with Adipofilling is efficacious and minimally invasive. Capurro S. (2020): Treatment of acne scars with subcutaneous and intradermal Adipofilling. www.crpub.org Medical Video Journal, Adipofilling section.