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Jack Szostak Nobel Laureate, 2009 Professor of Chemistry and Chemical Biology, Harvard University Professor, Department of Genetics, Harvard Medical School Alex Rich Distinguished Investigator, Department of Molecular Biology, Massachusetts General Hospital Investigator, Howard Hughes Medical Institute "The emergence of RNA from prebiotic mixtures of nucleotides” The first genetic polymers may have been nucleic acids with significant heterogeneity in the chemistry of their nucleobases, sugar components, and backbone connectivity. I will describe our ongoing efforts to explore the chemistry, structure and properties of potentially prebiotic versions of RNA, with particular emphasis on the effects of such variations on the process of nonenzymatic RNA replication. Our findings suggest a model for the transition from early heterogeneous nucleic acids to a more homogeneous form that is closer to modern RNA. The Origins of Life Speaker Series explores the conditions and circumstances that led to the diversity of life on Earth. The interdisciplinary series will connect the formation of planets, the evolution of early Earth, and the complex chemistry and delivery of the fundamental organic molecules that serve as the building blocks of early life, and how they can establish complex, self-replicating systems of cells and genetic material. Learn more: https://physicalsciences.uchicago.edu... ➡ Subscribe: / @physicalsciencesdivisionun8258 About the University of Chicago Physical Sciences Division The Physical Sciences Division (PSD) at the University of Chicago has a rich history of advancing and defining new fields of discovery in the physical and mathematical sciences, and this tradition of innovation continues today. Our inquiry and impact spans from the edge of the observable universe to human-computer interaction, from biophysical materials science to the geologic record of seawater composition, from gravitational waves to geometric flows, and beyond. The division includes the academic departments of Astronomy & Astrophysics, Chemistry, Computer Science, Geophysical Sciences, Mathematics, Physics, and Statistics. In addition, PSD is home to a number of interdisciplinary research institutes and centers, including the Enrico Fermi Institute, the James Franck Institute, and the Kavli Center for Cosmological Physics. #UChicagoPSD on the Web: Home: https://physicalsciences.uchicago.edu Facebook: / uchicagopsd Twitter: / uchicagopsd Instagram: / uchicagopsd University of Chicago Physical Sciences Division on YouTube: / @physicalsciencesdivisionun8258