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Why Weight Regain Happens After Weight Loss Medications

Weight regain after Ozempic, Wegovy, Mounjaro and other weight loss medications is common—and it’s not a willpower issue. In this episode of the Eating for You Podcast (157), as a non-diet, mindfulness-based dietitian, I explain what a 2025 systematic review found about weight regain after stopping weight loss medications, why it happens biologically, and how regain compares with lifestyle and behavioural programs. I go beyond the scale to talk about body composition—why preserving muscle (lean body mass) matters for metabolic health, ageing well, and reducing the proportion of fat regained. ✅ If you’re curious about weight loss meds, considering them, or already taking one, you’re welcome here—no shame, fear or blame. What you’ll learn: How GLP-1 medications work (appetite suppression + regulation) Common side effects (and the “hidden” effect on nutrition + movement) Why people stop these meds (side effects, cost, beliefs about short-term use, plateaus) What happens when you stop (and why regain is often biological) Medication regain vs lifestyle/behavioural program regain (what the research shows) A healthier question than “How do I keep the weight off forever?” Free support: Book a free 30-minute Mindful Eating Strategy Call: https://booknow.eatingforyou.com.au/ Newsletter: Get weekly Nourishment updates: https://eatingforyou.com.au/nourishment/ Movement support: Angela Mills can be contacted here: https://www.fitandfabulous.com.au/ Chapters 00:23 Ozempic, Wegovy & Mounjaro: Why this episode (no shame, no blame) 01:49 Weight regain after stopping weight loss medications: what the research asks 04:15 How GLP-1 weight loss medications work (appetite suppression + regulation) 05:50 Weight doesn’t equal health: why body composition matters 06:45 Subcutaneous vs visceral fat: what’s the difference? 08:18 Why visceral fat matters (insulin resistance, diabetes, heart risk) 10:54 Muscle loss & weight regain: why lean body mass is everything 13:29 Side effects of GLP-1 meds (nausea, reflux, constipation, fatigue) + hidden risks 15:11 Stopping GLP-1 meds: why many people quit (50% within 12 months + costs) 20:23 Medication regain vs lifestyle programs: timelines (1.7 years vs ~5 years) + what helps long term