neuraminidase inhibitor: Oseltamivir and zanamivir: Antiviral drugs lecture 7 скачать в хорошем качестве

neuraminidase inhibitor: Oseltamivir and zanamivir: Antiviral drugs lecture 7

this is last video of antiviral drugs and it contain neuraminidase inhibitor drugs like Oseltamivir and zanamivir Oseltamivir, sold under the brand name Tamiflu, is an antiviral medication used to treat and prevent influenza A and influenza B, viruses that cause the flu. Many medical organizations recommend it in people who have complications or are at high risk of complications within 48 hours of first symptoms of infection. Zanamivir is a medication used to treat and prevent influenza caused by influenza A and influenza B viruses. It is a neuraminidase inhibitor and was developed by the Australian biotech firm Biota Holdings. It was licensed to Glaxo in 1990 and approved in the US in 1999, only for use as a treatment for influenza this vadio also explain the function of neuraminidase enzyme , the mode of action of Oseltamivir and zanamivir, their side effect, antiviral spectrum and the resistance which are activated against these drugs neuraminidase, also called sialidase, any of a group of enzymes that cleave sialic acid, a carbohydrate occurring on the surfaces of cells in humans and other animals and in plants and microorganisms. The neuraminidase activity of NA protein plays a major role in the release of nascent viral particles assembled in infected cells. It facilitates the release of viral particles from cells by the cleavage of a sialic acid residue of glycan moiety linked to cellular glycoproteins in the plasma membrane. Zanamivir and Oseltamivir inhibit viral neuraminidase, an enzyme essential for release of newly formed virus particles from infected cells and further spread of the infectious virus. The most common adverse effects for Oseltamivir are nausea, vomiting, and diarrhea8. Zanamivir can cause bronchospasm when administered by inhalation4. The U.S. FDA has recently approved the intravenous use of peramivir5, but has not approved laninamivir for use. Oseltamivir, zanamivir, and peramivir are sialic acid analogues that inhibit influenza virus by competitively interacting with the neuraminidases of influenza A and B viruses. Influenza neuraminidase cleaves terminal sialic acid residues and destroys the receptors recognized by viral hem agglutinin. all hematology video lectures    • Hematology test lectures   all lecture on DNA as genetic material    • extra video lectures   All MHC lectures    • Over view of MHC molecules: MHC lecture 1   all virology video lectures    • virology lectures   lecture on all culture media used in microbiology    • Lecture or playlist of all culture media i...   all biochemical test video lectures    • All biochemical test video lecture   lectures on physical barriers of innate immune system    • Lectures of physical barriers of innate im...   lectures on antibiotics    • antibiotic vedio lectures   Lectures on cell biology    • cell biology lectures   letures on antiviral drugs    • antiviral drugs   lectures on antifungal    • Anti fungal video lectures   lectures on celiac disease    • celiac disease videos lectures   lectures on life cycle of basic viruses    • life cycle of basic viruses   lectures on chikungunia disease    • Lectures or playlist of chikungunya disease   lectures on DNA replication in prokaryotes and eukaryotes    • DNA replication in prokaryotes and eukaryo...   lectures on recombinant DNA technology    • Lectures of Recombinant DNA Technology in ...   lecture on B. Cell biology    • B cell biology lectures   lecture on T. Cell biology    • T cell biology lectures   immunology lectures    • Immunology lectures   lectures on complement system    • Lectures or playlist of complement system   lectures on antibodies    • Antibody lectures   lectures on inflammation    • Inflammation lectures   lectures on hypersensitivity    • Hypersensitive lectures   all cytokine lectures    • Lectures on Cytokine