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There is evidence that the circadian clock, which adjusts the body’s biology to the day’s natural cycle, regulates skin functions. For each hair growth cycle, hair follicles make new hair. The ability to regenerate hairs throughout life is from the hair stem cells in the hair follicle and the influence of the circadian rhythm. Once growth is complete during the anagen phase, clock genes are expressed in the hair cells at the bottom of the hair follicle. Thus, the circadian clock differs among the phases of the hair growth cycle.The circadian clock can adjust how the hair stem cells are turned off or on, which controls the hair growth cycles. For instance, through a clock gene called BMAL1, stem cell genes can be affected to become more or less active. If mutations arise in clock genes, such as deleting BMAL1, stem cells may become inactive leading to poor hair growth. Studies have shown that disrupting the circadian clock can prolong the phase of active hair growth. BMAL1 and PER1 are core clock genes in the human hair cycle. Because the circadian clock influences cell activity at different stages of the hair cycle, clock gene mutations can result in subtle hair cycle variations. These clock gene dysfunctions may cause certain disorders. The BMAL1 and PER1 clock genes produce signals that terminate the growth phase, anagen. Silencing both of these genes can prolong the hair growth cycle and lead to longer hair. Sunrise to sunset method will help you preserve your hair! --- Dr. Palaniappan Manickam MD, MPH Internal Medicine | Gastroenterology | Epidemiologist --- For Tamil videos, please subscribe to my Tamil channel: / @priyapal_vibes Like us on Facebook: / dr-pal-102856268051377 Follow us on Instagram: / dr.pal.manickam Follow us on Twitter: / drpal_manickam Join us on Telegram: https://t.me/Ask_Doc_Pal Email: [email protected] If you want to donate to AISHWARYAM TRUST, here are the details. Website: https://aishwaryamtrust.com/