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There is substantial evidence that cannabis and its constituent D9-tetrahydrocannabinol (THC) alleviate chronic pain in adult men and women. This effect is due to the ability of THC to interact with selective binding sites called cannabinoid receptors which are found on the surface of neurons and other cells. The lecture will outline the analgesic properties of cannabis and the mechanism underpinning such properties. There is substantial evidence that cannabis and its constituent D9-tetrahydrocannabinol (THC) alleviate chronic pain in adult men and women. This effect is due to the ability of THC to interact with selective binding sites called cannabinoid receptors which are found on the surface of neurons and other cells. The lecture will outline the analgesic properties of cannabis and the mechanism underpinning such properties.