Journal Club - 8 Days vs. 14 Days: Can We Shorten Antibiotics for Gram-Negative Sepsis? скачать в хорошем качестве

Journal Club - 8 Days vs. 14 Days: Can We Shorten Antibiotics for Gram-Negative Sepsis?

In this episode of Journal Club, Ben and Daphna review a retrospective cohort study from Pediatrics examining antibiotic duration for uncomplicated Gram-negative bloodstream infections in the NICU. The study, a collaboration between Nationwide Children’s Hospital and UT Health San Antonio, compares outcomes between short course (≤8 days) and long course (≥9 days) therapy. The hosts discuss the startling finding that while recurrence rates were similar, the long-duration group had a 14% rate of developing multi-drug resistant (MDR) infections within 90 days, compared to 0% in the short-duration group. Link to the article: https://pubmed.ncbi.nlm.nih.gov/41554...