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Thalassemia - This video is on the two main types of thalassemia i.e Alpha Thalassemia and Beta Thalassemia along with their clinical features, Diagnosis and Treatment. Video contains Definition of Thalassemia - 00:36 secs Types of Thalassemia - 01:32 minutes α -thalassemia - 01:59 minutes β-thalassemia - 04:20 minutes Thalassemia Minor - 05:05 minutes Thalassemia Major - 05:51 minutes Signs and Symptoms of Thalassemia - 07:49 minutes Diagnosis of Thalassemia (Lab Investigations) - 09:32 minutes NESTROFT test - 12:02 minutes Treatment of Thalassemia - 13:38 minutes The name of this group of diseases comes from the Greek word “thalasa”, meaning “sea”, because this disorder occurs more commonly among people living near the Mediterranean sea. Thalassemia Thalassemia is a group of genetically transmitted disorder of hemoglobin synthesis, due to lack or decreased synthesis of α or β globin chains. Types of thalassemia Depending upon whether the genetic defect lies in synthesis of α or β globin chains, thalassemia are classified into: α-thalassemia β-thalassemia respectively. α -thalassemia Synthesis of α -globin chain is defective. α -globin chains are coded by four copies of α -globin gene chromosome 16. The α -thalassemia results from genetic defect in one or more copies of α -globin genes and is characterized by either decreased or total absence of synthesis of α -globin chains. The α -thalassemia is of four types. β-thalassemia Synthesis of β-globin chain is impaired due to genetic defect in β-globin genes. β-globin chains are coded by two copies of β-globin genes chromosome 11 and is characterized by decreased or total absence of synthesis of β-globin chains. The β-thalassemia is of two types. -- β -thalassemia minor (β -thalassemia trait) -- β -thalassemia major