Generating Human Hindbrain Motor Neurons | 2025 Stanford 6th Annual Neuromuscular скачать в хорошем качестве

Generating Human Hindbrain Motor Neurons | 2025 Stanford 6th Annual Neuromuscular

Dr. Loh presented groundbreaking research on creating human hindbrain motor neurons from pluripotent stem cells, focusing on understanding bulbar symptoms in ALS and SMA patients. Dr. Loh, a Packard Fellow and Assistant Professor at Stanford, explained how hindbrain motor neurons control critical functions like eating, swallowing, and speech. He revealed that the brain originates from two distinct progenitor sources. This discovery, made over eight years, allows for the creation of massive quantities of human hindbrain motor neurons in the lab, potentially leading to better disease models and transplantation therapies. Dr. Loh's team demonstrated that these neurons are electrically active and evolutionarily conserved across species. The research also suggests the possibility of a third progenitor for spinal cord motor neurons, with plans to investigate cervical, thoracic, lumbar, and sacral motor neuron development. View accreditation information and claim CME at https://stanford.cloud-cme.com/course...