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Sepsis is a global health emergency affecting approximately 50 million people each year and resulting in at least 11 million deaths worldwide. These figures represent 20% of all-cause global mortality and do not consider the added burden contributed by COVID-19 over the past two and a half years. According to the World Health Organization, most sepsis deaths can be prevented through improved infection prevention, early recognition and management of sepsis as an emergency, in the same way a heart attack would be treated. Preventing global sepsis deaths, however, requires reinforcement of competencies on prevention, recognition and management for all health care workers and increasing sepsis awareness at all levels of society, including among lay people, policy makers and health care authorities. Encouraging milestones in the global fight against sepsis have been the adoption of a sepsis resolution “Improving Prevention, Recognition, Diagnosis and Clinical Management of Sepsis” at the 2017 World Health Assembly and its inclusion in the agenda of the G7 Health Ministers’ Meeting in 2022. We will address the global burden of sepsis and Antimicrobial Resistance (AMR), highlight initiatives in addressing sepsis in sub-Saharan Africa, present data on the effectiveness of increasing awareness for sepsis and prioritizing sepsis on all levels. Discuss the impact of the implementation of quality improvement measures, such as the education of health care workers in the early recognition of deteriorating patients and the availability of rapid response teams on survival. Finally, this workshop will provide insights on the poorly recognized potential of novel therapeutic approaches.