The science of xenotransplantation and how it can change our world скачать в хорошем качестве

The science of xenotransplantation and how it can change our world

On January 7th, 2022, the first successful xenotransplantation was performed at the University of Maryland Medical Center. By drawing on David Bennett's recent pig heart xenotransplantation, we explore the genetic modifications that made this surgery possible, explore the implications of the current surgery and how it will impact the organ transplant waiting list. This video was made by McMaster students Mohaimen Ibrahim, Anusha Desai, Hasan Salman, and Samara Hasan in collaboration with the McMaster Demystifying Medicine Program. Subscribe to the McMaster Demystifying Medicine YouTube channel:    / demystifyingmedicine   This video is provided for general and educational information only. Please consult your health care provider for Information about your health. Copyright McMaster University 2022 References: Bailey, L. L. (1985). Baboon-to-human cardiac xenotransplantation in a neonate. JAMA: The Journal of the American Medical Association, 254(23), 3321. https://doi.org/10.1001/jama.1985.033... Bender, M., Längin, M., Reichart, B., Mokelke, M., Radan, J., Neumann, E., Michel, S., Ellgass, R., Cowan, P. J., Wolf, E., Abicht, J. M., & Brenner, P. (2022). Clinical cardiac xenotransplantation first in the Clinical Arena. Xenotransplantation, 29(1). https://doi.org/10.1111/xen.12734 Byrne, G. W., & McGregor, C. G. A. (2012). Cardiac xenotransplantation. Current Opinion in Organ Transplantation, 17(2), 148–154. https://doi.org/10.1097/mot.0b013e328... Center for Biologics Evaluation and Research. (n.d.). Xenotransplantation. U.S. Food and Drug Administration. Retrieved March 2, 2022, from https://www.fda.gov/vaccines-blood-bi... Cooper, D. K. C., Ekser, B., Ramsoondar, J., Phelps, C., & Ayares, D. (2015). The role of Genetically Engineered Pigs in xenotransplantation research. The Journal of Pathology, 238(2), 288–299. https://doi.org/10.1002/path.4635 Greer, T. (n.d.). UAB announces first clinical-grade transplant of gene-edited pig kidneys into brain-dead human. UAB News. Retrieved March 2, 2022, from https://www.uab.edu/news/campus/item/... Hara, H., & Cooper, D. K. (2010). The Immunology of Corneal Xenotransplantation: A review of the literature. Xenotransplantation, 17(5), 338–349. https://doi.org/10.1111/j.1399-3089.2... Hawthorne, W. J. (2022). World first pig‐to‐human cardiac xenotransplantation. Xenotransplantation, 29(1). https://doi.org/10.1111/xen.12733 Hinrichs, A., Riedel, E. O., Klymiuk, N., Blutke, A., Kemter, E., Längin, M., Dahlhoff, M., Keßler, B., Kurome, M., Zakhartchenko, V., Jemiller, E. M., Ayares, D., Bidlingmaier, M., Flenkenthaler, F., Hrabĕ de Angelis, M., Arnold, G. J., Reichart, B., Fröhlich, T., & Wolf, E. (2020). Growth hormone receptor knockout to reduce the size of donor pigs for Preclinical Xenotransplantation Studies. Xenotransplantation, 28(2). https://doi.org/10.1111/xen.12664 Lu, T., Yang, B., Wang, R., & Qin, C. (2020). Xenotransplantation: Current status in preclinical research. Frontiers in Immunology, 10. https://doi.org/10.3389/fimmu.2019.03060 Längin, M., Mayr, T., Reichart, B., Michel, S., Buchholz, S., Guethoff, S., Dashkevich, A., Baehr, A., Egerer, S., Bauer, A., Mihalj, M., Panelli, A., Issl, L., Ying, J., Fresch, A. K., Buttgereit, I., Mokelke, M., Radan, J., Werner, F., … Abicht, J.-M. (2018). Consistent success in life-supporting Porcine cardiac xenotransplantation. Nature, 564(7736), 430–433. https://doi.org/10.1038/s41586-018-07... Pierson, R. N., Fishman, J. A., Lewis, G. D., D’Alessandro, D. A., Connolly, M. R., Burdorf, L., Madsen, J. C., & Azimzadeh, A. M. (2020). Progress toward cardiac xenotransplantation. Circulation, 142(14), 1389–1398. https://doi.org/10.1161/circulationah... Porrett, P. M., Orandi, B. J., Kumar, V., Houp, J., Anderson, D., Cozette Killian, A., Hauptfeld‐Dolejsek, V., Martin, D. E., Macedon, S., Budd, N., Stegner, K. L., Dandro, A., Kokkinaki, M., Kuravi, K. V., Reed, R. D., Fatima, H., Killian, J. T., Baker, G., Perry, J., … Locke, J. E. (2022). First clinical‐grade porcine kidney xenotransplant using a human decedent model. American Journal of Transplantation. https://doi.org/10.1111/ajt.16930 Reichart, B., Längin, M., Denner, J., Schwinzer, R., Cowan, P. J., & Wolf, E. (2021). Pathways to clinical cardiac xenotransplantation. Transplantation, 105(9), 1930–1943. https://doi.org/10.1097/tp.0000000000... Sachs, D. H., & Galli, C. (2009). Genetic manipulation in Pigs. Current Opinion in Organ Transplantation, 14(2), 148–153. https://doi.org/10.1097/mot.0b013e328... Yang, Y.-G., & Sykes, M. (2007). Xenotransplantation: Current status and a perspective on the future. Nature Reviews Immunology, 7(7), 519–531. https://doi.org/10.1038/nri2099