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In this video we present the top-viewed research articles published in each of JAMA Network’s journals from October 1, 2020, through September 30, 2021. For the second year, most articles were related to COVID-19, occupying the top-viewed article spot in 10 of the 13 journals. Despite the pandemic’s ongoing importance and prominence in medical publishing, the other 3 top-viewed articles were no less clinically valuable. Click https://ja.ma/3msUDdH for or complete details. Articles discussed in this video: 0:00 Introduction 0:18 Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial 0:35 SARS-CoV-2 Transmission From People Without COVID-19 Symptoms 0:54 Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder: A Randomized Clinical Trial 1:12 Myocarditis Following Immunization With mRNA COVID-19 Vaccines in Members of the US Military 1:37 Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study 2:02 Evaluation of Cloth Masks and Modified Procedure Masks as Personal Protective Equipment for the Public During the COVID-19 Pandemic 2:21 Delayed Localized Hypersensitivity Reactions to the Moderna COVID-19 Vaccine: A Case Series 2:43 Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome 3:02 Progression of Myopia in School-Aged Children After COVID-19 Home Confinement 3:22 Association of COVID-19 Vaccination and Facial Nerve Palsy: A Case-Control Study 3:42 Analyses of Risk, Racial Disparity, and Outcomes Among US Patients With Cancer and COVID-19 Infection 4:08 Survival After Breast Conservation vs Mastectomy Adjusted for Comorbidity and Socioeconomic Status: A Swedish National 6-Year Follow-up of 48 986 Women 4:32 Association of Wealth With Longevity in US Adults at Midlife